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KMID : 1023420070070010009
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Journal of Dental Hygiene Science
2007 Volume.7 No. 1 p.9 ~ p.12
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Glucosyltransferase Inhibition of Streptococcus mutans by Dioscorea batatas and Prunella vulgaris extract
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Jung Gi-Ok
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Abstract
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Streptococcus mutans is the major causative factor in dental caries and has been known to induce dental caries by the process of initial attachment proliferation and acid production. The pH of Streptococcus mutans(S. mutans) media and glucosyltransferase(GTase) activity were determined to evaluate the anticariogenic activity of Dioscorea batatas and Prunella vulgaris hexane fraction. In the experiment of hexane fraction of Dioscorea batatas, the relative growth ratio(RGR) against Streptococcus mutans (S. mutans) was determined as 93% in concentration of 0.125 mg/ml, 100% in 0.25 mg/ml. The hexane fraction of Prunella vulgaris revealed relative growth ratio(RGR) against Streptococcus mutans (S. mutans) as 86% in concentration of 0.25 mg/ml, 100% in 0.5 mg/ml. The relative growth ratio(RGR) against of hexane fraction were determined as 92% in concentration of 0.25 mg/ml, 100% in 0.5 mg/ml. The acidities were pH 7.2 on Dioscorea batatas and 7.0 on Prunella vulgaris in 2.0 mg/ml in contrast to pH 5.6 on Dioscorea batatas and 5.2 on Prunella vulgaris in control. The inhibitory effect to activity revealed 35% on Dioscorea batatas and 25% on Prunella vulgaris in 2.0 mg/ml. The inhibitory effect of Dioscorea batatas was more potent than Prunella vulgaris.
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KEYWORD
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Dioscorea batatas, Prunella vulgaris, Streptococcus mutans, Rrelative growth ratio, pH, Glucosyltransferase
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